{
  "annotation_id": "32002210-aba5-42b4-9453-d856c1ab411c",
  "date_created": "2026-03-02T18:01:34.411000Z",
  "date_modified": "2026-03-02T18:01:34.411000Z",
  "file_hash": "aae47f06893a27d57bcaeb1f28153a1bdc11a623654e0baaaf5abcc2923146b1",
  "private": false,
  "record": {
    "abstract": "We model the spontaneous assembly of a capsid (a virus\u0027s closed outer shell)\nfrom many copies of identical units, using entirely irreversible steps and only\ninformation local to the growing edge. Our model is formulated in terms of (i)\nan elastic Hamiltonian with stretching and bending stiffness and a spontaneous\ncurvature, and (ii) a set of rate constants for addition of new units or bonds.\nAn ensemble of highly irregular capsids is generated, unlike the well-known\nicosahedrally symmetric viruses, but (we argue) plausible as a way to model the\nirregular capsids of retroviruses such as HIV. We found that (i) the\nprobability of successful capsid completion decays exponentially with capsid\nsize; (ii) capsid size depends strongly on spontaneous curvature and weakly on\nthe ratio of the bending and stretching elastic stiffnesses of the shell; (iii)\nthe degree of localization of Gaussian curvature (a measure of facetedness)\ndepends heavily on the ratio of elastic stiffnesses.",
    "arxiv_id": "q-bio/0512035",
    "authors": [
      "Stephen D. Hicks",
      "C. L. Henley"
    ],
    "categories": [
      "q-bio.BM",
      "cond-mat.soft"
    ],
    "doi": "10.1103/PhysRevE.74.031912",
    "title": "An irreversible growth model for virus capsid assembly",
    "url": "https://arxiv.org/abs/q-bio/0512035"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "02290bd9-10c7-4f8c-90b7-e53f3ffa0f00",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}