dorsal/arxiv
View SchemaMechanisms of organogenesis of primary lymphoid follicles
| Authors | Tilo Beyer, Michael Meyer-Hermann |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0611058 |
| URL | https://arxiv.org/abs/q-bio/0611058 |
Abstract
Primary lymphoid follicles in secondary lymphoid tissue of mammals are the backbone for the formation of follicular dendritic cell networks. These are important for germinal center reactions. In the context of organogenesis molecular requirements for the formation of follicles have been identified. The present study complements this work with a simulation of the dynamics of the primary lymphoid follicle formation. In contrast to other problems of pattern formation, here, the homeostasis of the cell population is not governed by a growth-death balance but by a flow equilibrium of migrating cells. The influx of cells into secondary lymphoid tissue was extensively studied while less information is available about the efflux of lymphocytes from secondary lymphoid tissues. This study formulates the minimal requirements for cell efflux that guarantee a flow equilibrium and, thus, a stable primary lymphoid follicle. The model predicts that in addition to already identified mechanisms a negative regulation of the generation of follicular dendritic cells is required. Furthermore, a comparison with data concerning the microanatomy of secondary lymphoid tissues yields the conclusion that dynamical changes during the formation of FDC networks of the lymphatic endothelium are necessary to understand the genesis and maintenance of follicles.
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"abstract": "Primary lymphoid follicles in secondary lymphoid tissue of mammals are the\nbackbone for the formation of follicular dendritic cell networks. These are\nimportant for germinal center reactions. In the context of organogenesis\nmolecular requirements for the formation of follicles have been identified. The\npresent study complements this work with a simulation of the dynamics of the\nprimary lymphoid follicle formation. In contrast to other problems of pattern\nformation, here, the homeostasis of the cell population is not governed by a\ngrowth-death balance but by a flow equilibrium of migrating cells. The influx\nof cells into secondary lymphoid tissue was extensively studied while less\ninformation is available about the efflux of lymphocytes from secondary\nlymphoid tissues. This study formulates the minimal requirements for cell\nefflux that guarantee a flow equilibrium and, thus, a stable primary lymphoid\nfollicle. The model predicts that in addition to already identified mechanisms\na negative regulation of the generation of follicular dendritic cells is\nrequired. Furthermore, a comparison with data concerning the microanatomy of\nsecondary lymphoid tissues yields the conclusion that dynamical changes during\nthe formation of FDC networks of the lymphatic endothelium are necessary to\nunderstand the genesis and maintenance of follicles.",
"arxiv_id": "q-bio/0611058",
"authors": [
"Tilo Beyer",
"Michael Meyer-Hermann"
],
"categories": [
"q-bio.TO",
"q-bio.CB"
],
"title": "Mechanisms of organogenesis of primary lymphoid follicles",
"url": "https://arxiv.org/abs/q-bio/0611058"
},
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