{
  "annotation_id": "308758e5-9101-48cc-84d6-e31f5dbc3082",
  "date_created": "2026-03-02T18:01:31.920000Z",
  "date_modified": "2026-03-02T18:01:31.920000Z",
  "file_hash": "d14fc4cc5f2a9d4d4d50064b0d1cb70382e47a18643ee33f29efe773d6b32ea5",
  "private": false,
  "record": {
    "abstract": "To understand the mechanism of TATA-box conformational transformations we\nmodel structure mobility and find the types of conformational excitations of\nDNA macromolecule in heteronomous conformation. We have constructed the\ntwo-component model for describing DNA conformational transformation with\nsimultaneous transitions in the furanos rings of the monomer link. Internal\ncomponent describes the change of the base pair position in the double helix.\nExternal component describes the displacement of mass center of the monomer\nlink. Nonlinearity of the system is accounted with a form of potential energy\ndescribing C3\u0027-C2\u0027 and C2\u0027-C3\u0027 sugars transitions in monomer link, and\ninterrelation between monomer conformational transition and macromolecule\ndeformation. The comparison of our results with experimental data allows to\nconfirm that the localized conformational excitations may realise in DNA\nTATA-box. These excitations cause the deformation of the macromolecule\nfragment.",
    "arxiv_id": "q-bio/0412025",
    "authors": [
      "P. P. Kanevska",
      "S. N. Volkov"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "journal_ref": "Biophysical Bulletin (Kharkiv), 2004",
    "title": "Conformational transformations of DNA macromolecule in heteronomous   conformation",
    "url": "https://arxiv.org/abs/q-bio/0412025"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "128c5839-e009-41b3-a395-e3c012feada8",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}