{
  "annotation_id": "306c3138-017e-4809-bc48-5ff4969728c6",
  "date_created": "2026-03-02T18:01:35.555000Z",
  "date_modified": "2026-03-02T18:01:35.555000Z",
  "file_hash": "808b8630d5db94eda8128bafb3bdba819b4565a72c4ba70f793e75bfc5c1d11c",
  "private": false,
  "record": {
    "abstract": "The didemnins represent a versatile class of depsipeptides of marine origin\nand hold a great deal of potential for biomedical application. The biological\nand geographical origins of the didemnins are reviewed in addition to the\nchemical structures of the major didemnins. The biological mechanisms behind\nthe antiviral and anticancer effects of selected didemnins are summarized and\nthe special case of dehydrodidemnin B (Aplidin) is expounded upon including\nstructural characteristics, synthesis, pharmacological mechanism and a\ndiscussion of its current clinical trials as an anticancer agent.",
    "arxiv_id": "q-bio/0612040",
    "authors": [
      "Jonathan L. Belof"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "title": "Survey of the didemnins: A class of depsipeptide natural products with   promising biomedical applications",
    "url": "https://arxiv.org/abs/q-bio/0612040"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "86ea9bf0-0400-4f18-a1f0-f01e9dd2001b",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}