dorsal/arxiv
View SchemaSurvey of the didemnins: A class of depsipeptide natural products with promising biomedical applications
| Authors | Jonathan L. Belof |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0612040 |
| URL | https://arxiv.org/abs/q-bio/0612040 |
Abstract
The didemnins represent a versatile class of depsipeptides of marine origin and hold a great deal of potential for biomedical application. The biological and geographical origins of the didemnins are reviewed in addition to the chemical structures of the major didemnins. The biological mechanisms behind the antiviral and anticancer effects of selected didemnins are summarized and the special case of dehydrodidemnin B (Aplidin) is expounded upon including structural characteristics, synthesis, pharmacological mechanism and a discussion of its current clinical trials as an anticancer agent.
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"abstract": "The didemnins represent a versatile class of depsipeptides of marine origin\nand hold a great deal of potential for biomedical application. The biological\nand geographical origins of the didemnins are reviewed in addition to the\nchemical structures of the major didemnins. The biological mechanisms behind\nthe antiviral and anticancer effects of selected didemnins are summarized and\nthe special case of dehydrodidemnin B (Aplidin) is expounded upon including\nstructural characteristics, synthesis, pharmacological mechanism and a\ndiscussion of its current clinical trials as an anticancer agent.",
"arxiv_id": "q-bio/0612040",
"authors": [
"Jonathan L. Belof"
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"title": "Survey of the didemnins: A class of depsipeptide natural products with promising biomedical applications",
"url": "https://arxiv.org/abs/q-bio/0612040"
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