dorsal/arxiv
View SchemaProtein and DNA sequence determinants of thermophilic adaptation
| Authors | Konstantin B. Zeldovich, Igor N. Berezovsky, Eugene I. Shakhnovich |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0607004 |
| URL | https://arxiv.org/abs/q-bio/0607004 |
| DOI | 10.1371/journal.pcbi.0030005 |
Abstract
Prokaryotes living at extreme environmental temperatures exhibit pronounced signatures in the amino acid composition of their proteins and nucleotide compositions of their genomes reflective of adaptation to their thermal environments. However, despite significant efforts, the definitive answer of what are the genomic and proteomic compositional determinants of Optimal Growth Temperature of prokaryotic organisms remained elusive. Here the authors performed a comprehensive analysis of amino acid and nucleotide compositional signatures of thermophylic adaptation by exhaustively evaluating all combinations of amino acids and nucleotides as possible determinants of Optimal Growth Temperature for all prokaryotic organisms with fully sequences genomes.. The authors discovered that total concentration of seven amino acids in proteomes, IVYWREL, serves as a universal proteomic predictor of Optimal Growth Temperature in prokaryotes. Resolving the old-standing controversy the authors determined that the variation in nucleotide composition (increase of purine load, or A+G content with temperature) is largely a consequence of thermal adaptation of proteins. However, the frequency with which A and G nucleotides appear as nearest neighbors in genome sequences is strongly and independently correlated with Optimal Growth Temperature. as a result of codon bias in corresponding genomes. Together these results provide a complete picture of proteomic and genomic determinants of thermophilic adaptation.
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"abstract": "Prokaryotes living at extreme environmental temperatures exhibit pronounced\nsignatures in the amino acid composition of their proteins and nucleotide\ncompositions of their genomes reflective of adaptation to their thermal\nenvironments. However, despite significant efforts, the definitive answer of\nwhat are the genomic and proteomic compositional determinants of Optimal Growth\nTemperature of prokaryotic organisms remained elusive. Here the authors\nperformed a comprehensive analysis of amino acid and nucleotide compositional\nsignatures of thermophylic adaptation by exhaustively evaluating all\ncombinations of amino acids and nucleotides as possible determinants of Optimal\nGrowth Temperature for all prokaryotic organisms with fully sequences genomes..\nThe authors discovered that total concentration of seven amino acids in\nproteomes, IVYWREL, serves as a universal proteomic predictor of Optimal Growth\nTemperature in prokaryotes. Resolving the old-standing controversy the authors\ndetermined that the variation in nucleotide composition (increase of purine\nload, or A+G content with temperature) is largely a consequence of thermal\nadaptation of proteins. However, the frequency with which A and G nucleotides\nappear as nearest neighbors in genome sequences is strongly and independently\ncorrelated with Optimal Growth Temperature. as a result of codon bias in\ncorresponding genomes. Together these results provide a complete picture of\nproteomic and genomic determinants of thermophilic adaptation.",
"arxiv_id": "q-bio/0607004",
"authors": [
"Konstantin B. Zeldovich",
"Igor N. Berezovsky",
"Eugene I. Shakhnovich"
],
"categories": [
"q-bio.BM",
"q-bio.GN"
],
"doi": "10.1371/journal.pcbi.0030005",
"title": "Protein and DNA sequence determinants of thermophilic adaptation",
"url": "https://arxiv.org/abs/q-bio/0607004"
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