dorsal/arxiv
View SchemaUV-induced mutagenesis in Escherichia coli SOS response: A quantitative model
| Authors | Sandeep Krishna, Sergei Maslov, Kim Sneppen |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0701013 |
| URL | https://arxiv.org/abs/q-bio/0701013 |
| DOI | 10.1371/journal.pcbi.0030041.eor |
| Journal | PLoS Computational Biology, e41.eor (2007) |
Abstract
Escherichia coli bacteria respond to DNA damage by a highly orchestrated series of events known as the SOS response, regulated by transcription factors, protein-protein binding and active protein degradation. We present a dynamical model of the UV-induced SOS response, incorporating mutagenesis by the error-prone polymerase, Pol V. In our model, mutagenesis depends on a combination of two key processes: damage counting by the replication forks and a long term memory associated with the accumulation of UmuD'. Together, these provide a tight regulation of mutagenesis resulting, we show, in a "digital" turn-on and turn-off of Pol V. Our model provides a compact view of the topology and design of the SOS network, pinpointing the specific functional role of each of the regulatory processes. In particular, we suggest that the recently observed second peak in the activity of promoters in the SOS regulon (Friedman et al., 2005, PLoS Biol. 3, e238) is the result of a positive feedback from Pol V to RecA filaments.
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"abstract": "Escherichia coli bacteria respond to DNA damage by a highly orchestrated\nseries of events known as the SOS response, regulated by transcription factors,\nprotein-protein binding and active protein degradation. We present a dynamical\nmodel of the UV-induced SOS response, incorporating mutagenesis by the\nerror-prone polymerase, Pol V. In our model, mutagenesis depends on a\ncombination of two key processes: damage counting by the replication forks and\na long term memory associated with the accumulation of UmuD\u0027. Together, these\nprovide a tight regulation of mutagenesis resulting, we show, in a \"digital\"\nturn-on and turn-off of Pol V. Our model provides a compact view of the\ntopology and design of the SOS network, pinpointing the specific functional\nrole of each of the regulatory processes. In particular, we suggest that the\nrecently observed second peak in the activity of promoters in the SOS regulon\n(Friedman et al., 2005, PLoS Biol. 3, e238) is the result of a positive\nfeedback from Pol V to RecA filaments.",
"arxiv_id": "q-bio/0701013",
"authors": [
"Sandeep Krishna",
"Sergei Maslov",
"Kim Sneppen"
],
"categories": [
"q-bio.MN",
"cond-mat.other"
],
"doi": "10.1371/journal.pcbi.0030041.eor",
"journal_ref": "PLoS Computational Biology, e41.eor (2007)",
"title": "UV-induced mutagenesis in Escherichia coli SOS response: A quantitative model",
"url": "https://arxiv.org/abs/q-bio/0701013"
},
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