{
  "annotation_id": "2a0bc795-2c75-4f07-b93c-0cb877276e52",
  "date_created": "2026-03-02T18:01:35.498000Z",
  "date_modified": "2026-03-02T18:01:35.498000Z",
  "file_hash": "66f758d07ed0f76bb41e303a75c90b9fff85328747f64af694dd9f90576bdd6a",
  "private": false,
  "record": {
    "abstract": "Using a theoretical model for spontaneous partial DNA unwrapping from\nhistones, we study the transient exposure of protein-binding DNA sites within\nnucleosomes. We focus on the functional dependence of the rates for site\nexposure and reburial on the site position, which is measurable experimentally\nand pertinent to gene regulation. We find the dependence to be roughly\ndescribed by a random walker model. Close inspection reveals a surprising\nphysical effect of flexibility-assisted barrier crossing, which we characterize\nwithin a toy model, the \"semiflexible Brownian rotor.\"",
    "arxiv_id": "q-bio/0605017",
    "authors": [
      "Wolfram Mobius",
      "Richard A. Neher",
      "Ulrich Gerland"
    ],
    "categories": [
      "q-bio.SC"
    ],
    "doi": "10.1103/PhysRevLett.97.208102",
    "journal_ref": "Phys. Rev. Lett. 97, 208102 (2006)",
    "title": "Kinetic Accessibility of Buried DNA Sites in Nucleosomes",
    "url": "https://arxiv.org/abs/q-bio/0605017"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "d0f0fead-2c1a-4833-8a4b-407b6c72841d",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}