dorsal/arxiv
View SchemaSensitivity dependent model of protein-protein interaction networks
| Authors | Jingshan Zhang, Eugene I. Shakhnovich |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0612029 |
| URL | https://arxiv.org/abs/q-bio/0612029 |
| DOI | 10.1088/1478-3975/5/3/036011 |
| Journal | Physical Biology 5, 036011 (2008) |
| License | http://arxiv.org/licenses/nonexclusive-distrib/1.0/ |
Abstract
The scale free structure p(k)~k^{-gamma} of protein-protein interaction networks can be reproduced by a static physical model in simulation. We inspect the model theoretically, and find the key reason for the model to generate apparent scale free degree distributions. This explanation provides a generic mechanism of "scale free" networks. Moreover, we predict the dependence of gamma on experimental protein concentrations or other sensitivity factors in detecting interactions, and find experimental evidence to support the prediction.
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"abstract": "The scale free structure p(k)~k^{-gamma} of protein-protein interaction\nnetworks can be reproduced by a static physical model in simulation. We inspect\nthe model theoretically, and find the key reason for the model to generate\napparent scale free degree distributions. This explanation provides a generic\nmechanism of \"scale free\" networks. Moreover, we predict the dependence of\ngamma on experimental protein concentrations or other sensitivity factors in\ndetecting interactions, and find experimental evidence to support the\nprediction.",
"arxiv_id": "q-bio/0612029",
"authors": [
"Jingshan Zhang",
"Eugene I. Shakhnovich"
],
"categories": [
"q-bio.MN",
"physics.bio-ph"
],
"doi": "10.1088/1478-3975/5/3/036011",
"journal_ref": "Physical Biology 5, 036011 (2008)",
"license": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
"title": "Sensitivity dependent model of protein-protein interaction networks",
"url": "https://arxiv.org/abs/q-bio/0612029"
},
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