dorsal/arxiv
View SchemaGene expression analysis reveals a strong signature of an interferon induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer
| Authors | Uri Einav, Yuval Tabach, Gad Getz, Assif Yitzhaky, Ugur Ozbek, Ninette Amariglio, Shai Izraeli, Gideon Rechavi, Eytan Domany |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0511017 |
| URL | https://arxiv.org/abs/q-bio/0511017 |
| Journal | Oncogene vol 24 p 6367 (2005) |
Abstract
On the basis of epidemiological studies, infection was suggested to play a role in the etiology of human cancer. While for some cancers such a role was indeed demonstrated, there is no direct biological support for the role of viral pathogens in the pathogenesis of childhood leukemia. Using a novel bioinformatic tool, that alternates between clustering and standard statistical methods of analysis, we performed a "double blind" search of published gene expression data of subjects with different childhood ALL subtypes, looking for unanticipated partitions of patients, induced by unexpected groups of genes with correlated expression. We discovered a group of about thirty genes, related to the interferon response pathway, whose expression levels divide the ALL samples into two subgroups; high in 50, low in 285 patients. Leukemic subclasses prevalent in early childhood (the age most susceptible to infection) are over-represented in the high expression subgroup. Similar partitions, induced by the same genes, were found also in breast and ovarian cancer but not in lung cancer, prostate cancer and lymphoma. About 40% of breast cancer samples expressed the "interferon- related" signature. It is of interested that several studies demonstrated MMTV-like sequences in about 40% of breast cancer samples. Our discovery of an unanticipated strong signature of an interferon induced pathway provides molecular support for a role for either inflammation or viral infection in the pathogenesis of childhood leukemia as well as breast and ovarian cancer.
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"abstract": "On the basis of epidemiological studies, infection was suggested to play a\nrole in the etiology of human cancer. While for some cancers such a role was\nindeed demonstrated, there is no direct biological support for the role of\nviral pathogens in the pathogenesis of childhood leukemia. Using a novel\nbioinformatic tool, that alternates between clustering and standard statistical\nmethods of analysis, we performed a \"double blind\" search of published gene\nexpression data of subjects with different childhood ALL subtypes, looking for\nunanticipated partitions of patients, induced by unexpected groups of genes\nwith correlated expression. We discovered a group of about thirty genes,\nrelated to the interferon response pathway, whose expression levels divide the\nALL samples into two subgroups; high in 50, low in 285 patients. Leukemic\nsubclasses prevalent in early childhood (the age most susceptible to infection)\nare over-represented in the high expression subgroup. Similar partitions,\ninduced by the same genes, were found also in breast and ovarian cancer but not\nin lung cancer, prostate cancer and lymphoma. About 40% of breast cancer\nsamples expressed the \"interferon- related\" signature. It is of interested that\nseveral studies demonstrated MMTV-like sequences in about 40% of breast cancer\nsamples. Our discovery of an unanticipated strong signature of an interferon\ninduced pathway provides molecular support for a role for either inflammation\nor viral infection in the pathogenesis of childhood leukemia as well as breast\nand ovarian cancer.",
"arxiv_id": "q-bio/0511017",
"authors": [
"Uri Einav",
"Yuval Tabach",
"Gad Getz",
"Assif Yitzhaky",
"Ugur Ozbek",
"Ninette Amariglio",
"Shai Izraeli",
"Gideon Rechavi",
"Eytan Domany"
],
"categories": [
"q-bio.GN",
"q-bio.MN"
],
"journal_ref": "Oncogene vol 24 p 6367 (2005)",
"title": "Gene expression analysis reveals a strong signature of an interferon induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer",
"url": "https://arxiv.org/abs/q-bio/0511017"
},
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