{
  "annotation_id": "24a12761-bf00-4541-b4a4-fc2e0de33a2a",
  "date_created": "2026-03-02T18:01:28.638000Z",
  "date_modified": "2026-03-02T18:01:28.638000Z",
  "file_hash": "ee7798f3d28841349cc5b5859c2f116f8e20f3f5fc9e281fc926f514a5a8cdfd",
  "private": false,
  "record": {
    "abstract": "This paper studies the emergence of multi-stability and hysteresis in those\nsystems that arise, under positive feedback, starting from monotone systems\nwith well-defined steady-state responses. Such feedback configurations appear\nroutinely in several fields of application, and especially in biology.\nCharacterizations of global stability behavior are stated in terms of easily\ncheckable graphical conditions. An example of a signaling cascade under\npositive feedback is presented.",
    "arxiv_id": "q-bio/0309002",
    "authors": [
      "David Angeli",
      "Eduardo D. Sontag"
    ],
    "categories": [
      "q-bio.QM",
      "q-bio.MN"
    ],
    "title": "Multi-Stability in Monotone Input/Output Systems",
    "url": "https://arxiv.org/abs/q-bio/0309002"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "ea29106d-6126-4d2b-92aa-5947c63d60bb",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}