dorsal/arxiv
View SchemaVascular network remodeling via vessel cooption, regression and growth in tumors
| Authors | K. Bartha, H. Rieger |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0506039 |
| URL | https://arxiv.org/abs/q-bio/0506039 |
| DOI | 10.1016/j.jtbi.2006.01.022 |
| Journal | J. Theor. Biol. 241, 903 (2006) |
Abstract
The transformation of the regular vasculature in normal tissue into a highly inhomogeneous tumor specific capillary network is described by a theoretical model incorporating tumor growth, vessel cooption, neo-vascularization, vessel collapse and cell death. Compartmentalization of the tumor into several regions differing in vessel density, diameter and in necrosis is observed for a wide range of parameters in agreement with the vessel morphology found in human melanoma. In accord with data for human melanoma the model predicts, that microvascular density (MVD, regarded as an important diagnostic tool in cancer treatment, does not necessarily determine the tempo of tumor progression. Instead it is suggested, that the MVD of the original tissue as well as the metabolic demand of the individual tumor cell plays the major role in the initial stages of tumor growth.
{
"annotation_id": "23b2fffe-0e68-47be-b039-12d289ed7758",
"date_created": "2026-03-02T18:01:31.812000Z",
"date_modified": "2026-03-02T18:01:31.812000Z",
"file_hash": "82c0f6c596c5929470c8f8d74000d821ec47fb9a8b8e4a7bea9af68f733b0220",
"private": false,
"record": {
"abstract": "The transformation of the regular vasculature in normal tissue into a highly\ninhomogeneous tumor specific capillary network is described by a theoretical\nmodel incorporating tumor growth, vessel cooption, neo-vascularization, vessel\ncollapse and cell death. Compartmentalization of the tumor into several regions\ndiffering in vessel density, diameter and in necrosis is observed for a wide\nrange of parameters in agreement with the vessel morphology found in human\nmelanoma. In accord with data for human melanoma the model predicts, that\nmicrovascular density (MVD, regarded as an important diagnostic tool in cancer\ntreatment, does not necessarily determine the tempo of tumor progression.\nInstead it is suggested, that the MVD of the original tissue as well as the\nmetabolic demand of the individual tumor cell plays the major role in the\ninitial stages of tumor growth.",
"arxiv_id": "q-bio/0506039",
"authors": [
"K. Bartha",
"H. Rieger"
],
"categories": [
"q-bio.TO",
"physics.bio-ph",
"q-bio.CB"
],
"doi": "10.1016/j.jtbi.2006.01.022",
"journal_ref": "J. Theor. Biol. 241, 903 (2006)",
"title": "Vascular network remodeling via vessel cooption, regression and growth in tumors",
"url": "https://arxiv.org/abs/q-bio/0506039"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "3423916b-abd0-46be-b9a3-5a7bc6811eb0",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}