dorsal/arxiv
View SchemaBayesian Inference Applied to the Electromagnetic Inverse Problem
| Authors | David M. Schmidt, John S. George, C. C. Wood |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0309029 |
| URL | https://arxiv.org/abs/q-bio/0309029 |
Abstract
We present a new approach to the electromagnetic inverse problem that explicitly addresses the ambiguity associated with its ill-posed character. Rather than calculating a single ``best'' solution according to some criterion, our approach produces a large number of likely solutions that both fit the data and any prior information that is used. While the range of the different likely results is representative of the ambiguity in the inverse problem even with prior information present, features that are common across a large number of the different solutions can be identified and are associated with a high degree of probability. This approach is implemented and quantified within the formalism of Bayesian inference which combines prior information with that from measurement in a common framework using a single measure. To demonstrate this approach, a general neural activation model is constructed that includes a variable number of extended regions of activation and can incorporate a great deal of prior information on neural current such as information on location, orientation, strength and spatial smoothness. Taken together, this activation model and the Bayesian inferential approach yield estimates of the probability distributions for the number, location, and extent of active regions. Both simulated MEG data and data from a visual evoked response experiment are used to demonstrate the capabilities of this approach.
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"abstract": "We present a new approach to the electromagnetic inverse problem that\nexplicitly addresses the ambiguity associated with its ill-posed character.\nRather than calculating a single ``best\u0027\u0027 solution according to some criterion,\nour approach produces a large number of likely solutions that both fit the data\nand any prior information that is used. While the range of the different likely\nresults is representative of the ambiguity in the inverse problem even with\nprior information present, features that are common across a large number of\nthe different solutions can be identified and are associated with a high degree\nof probability. This approach is implemented and quantified within the\nformalism of Bayesian inference which combines prior information with that from\nmeasurement in a common framework using a single measure. To demonstrate this\napproach, a general neural activation model is constructed that includes a\nvariable number of extended regions of activation and can incorporate a great\ndeal of prior information on neural current such as information on location,\norientation, strength and spatial smoothness. Taken together, this activation\nmodel and the Bayesian inferential approach yield estimates of the probability\ndistributions for the number, location, and extent of active regions. Both\nsimulated MEG data and data from a visual evoked response experiment are used\nto demonstrate the capabilities of this approach.",
"arxiv_id": "q-bio/0309029",
"authors": [
"David M. Schmidt",
"John S. George",
"C. C. Wood"
],
"categories": [
"q-bio.NC",
"q-bio.QM"
],
"title": "Bayesian Inference Applied to the Electromagnetic Inverse Problem",
"url": "https://arxiv.org/abs/q-bio/0309029"
},
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