{
  "annotation_id": "21fcd0a5-ed03-46b5-98cd-931e4a88bdcd",
  "date_created": "2026-03-02T18:01:35.589000Z",
  "date_modified": "2026-03-02T18:01:35.589000Z",
  "file_hash": "4193129bcfda5d32d53917edcf4724749b47f3091b17b81259ec18327905ccfe",
  "private": false,
  "record": {
    "abstract": "Molecular chaperones play a prominent role in signaling and transcriptional\nregulatory networks of the cell. Recent advances uncovered that chaperones act\nas genetic buffers stabilizing the phenotype of various cells and organisms and\nmay serve as potential regulators of evolvability. Chaperones have weak links,\nconnect hubs, are in the overlaps of network modules and may uncouple these\nmodules during stress, which gives an additional protection for the cell at the\nnetwork-level. Moreover, after stress chaperones are essential to re-build\ninter-modular contacts by their low affinity sampling of the potential\ninteraction partners in different modules. This opens the way to the\nchaperone-regulated modular evolution of cellular networks, and helps us to\ndesign novel therapeutic and anti-aging strategies.",
    "arxiv_id": "q-bio/0701030",
    "authors": [
      "Tamas Korcsmaros",
      "Istvan A. Kovacs",
      "Mate S. Szalay",
      "Peter Csermely"
    ],
    "categories": [
      "q-bio.MN"
    ],
    "journal_ref": "J. Biosciences (2007) 32, 441-446",
    "title": "Molecular chaperones: The modular evolution of cellular networks",
    "url": "https://arxiv.org/abs/q-bio/0701030"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "af47112d-fa6e-443b-9dbe-27d6993d7499",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}