{
  "annotation_id": "219659fe-3178-462d-a1ca-5bbc6e9d964b",
  "date_created": "2026-03-02T18:01:31.537000Z",
  "date_modified": "2026-03-02T18:01:31.537000Z",
  "file_hash": "8b94aedcd3a02d33ff460f3d8a53f930eb2e3d743870a0a166b1f539fad2c836",
  "private": false,
  "record": {
    "abstract": "We demonstrate a novel all-optical switch consisting of two molecules: a\nprimary fluorophore that can be switched between a fluorescent and a dark state\nby light of different wavelengths, and a secondary chromophore that facilitates\nswitching. The interaction between the two molecules exhibits a distance\ndependence much steeper than that of Forster resonance energy transfer. This\nenables the switch to act as a ruler with the capability to probe distances\ndifficult to access by other spectroscopic methods, thus presenting a new tool\nfor the study of biomolecules at the single-molecule level.",
    "arxiv_id": "q-bio/0502012",
    "authors": [
      "Mark Bates",
      "Timothy R. Blosser",
      "Xiaowei Zhuang"
    ],
    "categories": [
      "q-bio.QM",
      "physics.bio-ph",
      "physics.chem-ph",
      "q-bio.BM"
    ],
    "doi": "10.1103/PhysRevLett.94.108101",
    "title": "Short-range spectroscopic ruler based on a single-molecule optical   switch",
    "url": "https://arxiv.org/abs/q-bio/0502012"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "2661c477-ae7d-401c-86cf-70ddcb97c736",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}