dorsal/arxiv
View SchemaShort-range spectroscopic ruler based on a single-molecule optical switch
| Authors | Mark Bates, Timothy R. Blosser, Xiaowei Zhuang |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0502012 |
| URL | https://arxiv.org/abs/q-bio/0502012 |
| DOI | 10.1103/PhysRevLett.94.108101 |
Abstract
We demonstrate a novel all-optical switch consisting of two molecules: a primary fluorophore that can be switched between a fluorescent and a dark state by light of different wavelengths, and a secondary chromophore that facilitates switching. The interaction between the two molecules exhibits a distance dependence much steeper than that of Forster resonance energy transfer. This enables the switch to act as a ruler with the capability to probe distances difficult to access by other spectroscopic methods, thus presenting a new tool for the study of biomolecules at the single-molecule level.
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"abstract": "We demonstrate a novel all-optical switch consisting of two molecules: a\nprimary fluorophore that can be switched between a fluorescent and a dark state\nby light of different wavelengths, and a secondary chromophore that facilitates\nswitching. The interaction between the two molecules exhibits a distance\ndependence much steeper than that of Forster resonance energy transfer. This\nenables the switch to act as a ruler with the capability to probe distances\ndifficult to access by other spectroscopic methods, thus presenting a new tool\nfor the study of biomolecules at the single-molecule level.",
"arxiv_id": "q-bio/0502012",
"authors": [
"Mark Bates",
"Timothy R. Blosser",
"Xiaowei Zhuang"
],
"categories": [
"q-bio.QM",
"physics.bio-ph",
"physics.chem-ph",
"q-bio.BM"
],
"doi": "10.1103/PhysRevLett.94.108101",
"title": "Short-range spectroscopic ruler based on a single-molecule optical switch",
"url": "https://arxiv.org/abs/q-bio/0502012"
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