dorsal/arxiv
View SchemaFast DNA translocation through a solid-state nanopore
| Authors | Arnold J. Storm, Cornelis Storm, Jianghua Chen, Henny Zandbergen, Jean-Francois Joanny, Cees Dekker |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0404041 |
| URL | https://arxiv.org/abs/q-bio/0404041 |
| DOI | 10.1021/nl048030d |
Abstract
We report translocation experiments on double-strand DNA through a silicon oxide nanopore. Samples containing DNA fragments with seven different lengths between 2000 to 96000 basepairs have been electrophoretically driven through a 10 nm pore. We find a power-law scaling of the translocation time versus length, with an exponent of 1.26 $\pm$ 0.07. This behavior is qualitatively different from the linear behavior observed in similar experiments performed with protein pores. We address the observed nonlinear scaling in a theoretical model that describes experiments where hydrodynamic drag on the section of the polymer outside the pore is the dominant force counteracting the driving. We show that this is the case in our experiments and derive a power-law scaling with an exponent of 1.18, in excellent agreement with our data.
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"abstract": "We report translocation experiments on double-strand DNA through a silicon\noxide nanopore. Samples containing DNA fragments with seven different lengths\nbetween 2000 to 96000 basepairs have been electrophoretically driven through a\n10 nm pore. We find a power-law scaling of the translocation time versus\nlength, with an exponent of 1.26 $\\pm$ 0.07. This behavior is qualitatively\ndifferent from the linear behavior observed in similar experiments performed\nwith protein pores. We address the observed nonlinear scaling in a theoretical\nmodel that describes experiments where hydrodynamic drag on the section of the\npolymer outside the pore is the dominant force counteracting the driving. We\nshow that this is the case in our experiments and derive a power-law scaling\nwith an exponent of 1.18, in excellent agreement with our data.",
"arxiv_id": "q-bio/0404041",
"authors": [
"Arnold J. Storm",
"Cornelis Storm",
"Jianghua Chen",
"Henny Zandbergen",
"Jean-Francois Joanny",
"Cees Dekker"
],
"categories": [
"q-bio.BM",
"cond-mat.soft",
"physics.bio-ph"
],
"doi": "10.1021/nl048030d",
"title": "Fast DNA translocation through a solid-state nanopore",
"url": "https://arxiv.org/abs/q-bio/0404041"
},
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