dorsal/arxiv
View SchemaModel of the early development of thalamo-cortical connections and area patterning via signaling molecules
| Authors | Jan Karbowski, G. B. Ermentrout |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0410002 |
| URL | https://arxiv.org/abs/q-bio/0410002 |
| Journal | Journal of Computational Neuroscience 17: 347-363 (2004) |
Abstract
The mammalian cortex is divided into architectonic and functionally distinct areas. There is growing experimental evidence that their emergence and development is controlled by both epigenetic and genetic factors. The latter were recently implicated as dominating the early cortical area specification. In this paper, we present a theoretical model that explicitly considers the genetic factors and that is able to explain several sets of experiments on cortical area regulation involving transcription factors Emx2 and Pax6, and fibroblast growth factor FGF8. The model consists of the dynamics of thalamo- cortical connections modulated by signaling molecules that are regulated genetically, and by axonal competition for neocortical space. The model can make predictions and provides a basic mathematical framework for the early development of the thalamo-cortical connections and area patterning that can be further refined as more experimental facts become known.
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"abstract": "The mammalian cortex is divided into architectonic and functionally distinct\nareas. There is growing experimental evidence that their emergence and\ndevelopment is controlled by both epigenetic and genetic factors. The latter\nwere recently implicated as dominating the early cortical area specification.\nIn this paper, we present a theoretical model that explicitly considers the\ngenetic factors and that is able to explain several sets of experiments on\ncortical area regulation involving transcription factors Emx2 and Pax6, and\nfibroblast growth factor FGF8. The model consists of the dynamics of thalamo-\ncortical connections modulated by signaling molecules that are regulated\ngenetically, and by axonal competition for neocortical space. The model can\nmake predictions and provides a basic mathematical framework for the early\ndevelopment of the thalamo-cortical connections and area patterning that can be\nfurther refined as more experimental facts become known.",
"arxiv_id": "q-bio/0410002",
"authors": [
"Jan Karbowski",
"G. B. Ermentrout"
],
"categories": [
"q-bio.NC",
"q-bio.MN"
],
"journal_ref": "Journal of Computational Neuroscience 17: 347-363 (2004)",
"title": "Model of the early development of thalamo-cortical connections and area patterning via signaling molecules",
"url": "https://arxiv.org/abs/q-bio/0410002"
},
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