{
  "annotation_id": "1f555974-5fb5-4c4d-b1eb-0628c750f774",
  "date_created": "2026-03-02T18:01:31.020000Z",
  "date_modified": "2026-03-02T18:01:31.020000Z",
  "file_hash": "131f8a2e96f631eeb853e1fdf044a5e2530594cacc88aa8d0709a2afe39d5440",
  "private": false,
  "record": {
    "abstract": "With the number of fully-sequenced genomes now well over a hundred it has\nbecome possible to start investigating if there are any quantitative\nregularities in the genetic make-up of genomes. In (physics/0307001), I\noriginally showed that the numbers of genes in different functional categories\nscale as power laws in the total number of genes in the genome. In this chapter\nI revisit these results with more recent data and go into considerable more\ndepth regarding the implications of these scaling laws for our understanding of\nthe regulatory design of cells. In addition, I further develop the evolutionary\nmodel first proposed in (physics/0307001), which suggests that the exponents of\nthe observed scaling laws correspond to fundamental constants of the\nevolutionary process. In particular, I put forward an hypothesis for the\napproximately quadratic scaling of regulatory and signal transducing genes with\ngenome size.",
    "arxiv_id": "q-bio/0405022",
    "authors": [
      "Erik van Nimwegen"
    ],
    "categories": [
      "q-bio.GN",
      "q-bio.MN"
    ],
    "title": "Scaling laws in the functional content of genomes: Fundamental constants   of evolution?",
    "url": "https://arxiv.org/abs/q-bio/0405022"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "257122c9-deec-4b4e-b704-f52713b25239",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}