dorsal/arxiv
View SchemaA possible role of chemotaxis in germinal center formation
| Authors | Tilo Beyer, Michael Meyer-Hermann, Gerhard Soff |
|---|---|
| Categories | |
| ArXiv ID | physics/0206026 |
| URL | https://arxiv.org/abs/physics/0206026 |
Abstract
During the germinal center reaction a characteristic morphology is developed. In the framework of a recently developed space-time-model for the germinal center a mechanism for the formation of dark and light zones has been proposed. The mechanism is based on a diffusing differentiation signal which is secerned by follicular dendritic cells. Here, we investigate a possible influence of recently found chemokines for the germinal center formation in the framework of a single-cell-based stochastic and discrete three-dimensional model. We will also consider alternative possible chemotactic pathways that may play a role for the development of both zones. Our results suggest that the centrocyte motility resulting from a follicular dendritic cell-derived chemokine has to exceed a lower limit to allow the separation of centroblasts and centrocytes. In contrast to light microscopy the dark zone is ring shaped. This suggests that FDC-derived chemoattractants alone cannot explain the typical germinal center morphology.
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"abstract": "During the germinal center reaction a characteristic morphology is developed.\nIn the framework of a recently developed space-time-model for the germinal\ncenter a mechanism for the formation of dark and light zones has been proposed.\nThe mechanism is based on a diffusing differentiation signal which is secerned\nby follicular dendritic cells. Here, we investigate a possible influence of\nrecently found chemokines for the germinal center formation in the framework of\na single-cell-based stochastic and discrete three-dimensional model. We will\nalso consider alternative possible chemotactic pathways that may play a role\nfor the development of both zones. Our results suggest that the centrocyte\nmotility resulting from a follicular dendritic cell-derived chemokine has to\nexceed a lower limit to allow the separation of centroblasts and centrocytes.\nIn contrast to light microscopy the dark zone is ring shaped. This suggests\nthat FDC-derived chemoattractants alone cannot explain the typical germinal\ncenter morphology.",
"arxiv_id": "physics/0206026",
"authors": [
"Tilo Beyer",
"Michael Meyer-Hermann",
"Gerhard Soff"
],
"categories": [
"physics.bio-ph",
"q-bio"
],
"title": "A possible role of chemotaxis in germinal center formation",
"url": "https://arxiv.org/abs/physics/0206026"
},
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