{
  "annotation_id": "1d3b06bb-48ba-4e16-981c-08c727c273b5",
  "date_created": "2026-03-02T18:01:31.674000Z",
  "date_modified": "2026-03-02T18:01:31.674000Z",
  "file_hash": "5fea7f4899b11c74a7b3231ada6db7a2b746cdb74e02cced67fdd6568984ad37",
  "private": false,
  "record": {
    "abstract": "We describe the representation of the chemical affinity between the\nantigen-combining site of the immunoglobulin molecule and the antigen molecule\nas the probability of the two molecules existing in a bound state. Our model is\nbased on the identification of shape attractors in the configuration space for\nthe joint antibody / antigen combining site sequence. We parameterize\nconfiguration space in terms of Ramachandran angles. The shape attractors allow\nus to construct a Markov chain whose steady state distribution gives rise to\nthe desired attachment probability. As a result we are able to delineate the\nenthalpic, entropic and kinetic components of affinity and study their\ninteractions.",
    "arxiv_id": "q-bio/0406012",
    "authors": [
      "Patricia Theodosopoulos",
      "Ted Theodosopoulos"
    ],
    "categories": [
      "q-bio.QM",
      "q-bio.BM",
      "q-bio.PE"
    ],
    "title": "A computational study of the statistical mechanics of antibody-antigen   conformations",
    "url": "https://arxiv.org/abs/q-bio/0406012"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "c964f516-c865-4426-903c-6f45d32e555c",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}