dorsal/arxiv
View SchemaComparative Analysis of the Saccharomyces cerevisiae and Caenorhabditis elegans Protein Interaction Network
| Authors | Ino Agrafioti, Jonathan Swire, James Abbott, Derek Huntley, Sarah Butcher, Michael P. H. Stumpf |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0503008 |
| URL | https://arxiv.org/abs/q-bio/0503008 |
| Journal | BMC Evolutionary Biology 2005, 5:23 |
Abstract
Protein interaction networks aim to summarize the complex interplay of proteins in an organism. Early studies suggested that the position of a protein in the network determines its evolutionary rate but there has been considerable disagreement as to what extent other factors, such as protein abundance, modify this reported dependence. We compare the genomes of Saccharomyces cerevisiae and Caenorhabditis elegans with those of closely related species to elucidate the recent evolutionary history of their respective protein interaction networks. Interaction and expression data are studied in the light of a detailed phylogenetic analysis. The underlying network structure is incorporated explicitly into the statistical analysis. The increased phylogenetic resolution, paired with high-quality interaction data, allows us to resolve the way in which protein interaction network structure and abundance of proteins affect the evolutionary rate. We find that expression levels are better predictors of the evolutionary rate than a protein's connectivity. Detailed analysis of the two organisms also shows that the evolutionary rates of interacting proteins are not sufficiently similar to be mutually predictive. It appears that meaningful inferences about the evolution of protein interaction networks require comparative analysis of reasonably closely related species. The signature of protein evolution is shaped by a protein's abundance in the organism and its function and the biological process it is involved in. Its position in the interaction networks and its connectivity may modulate this but they appear to have only minor influence on a protein's evolutionary rate.
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"abstract": "Protein interaction networks aim to summarize the complex interplay of\nproteins in an organism. Early studies suggested that the position of a protein\nin the network determines its evolutionary rate but there has been considerable\ndisagreement as to what extent other factors, such as protein abundance, modify\nthis reported dependence.\n We compare the genomes of Saccharomyces cerevisiae and Caenorhabditis elegans\nwith those of closely related species to elucidate the recent evolutionary\nhistory of their respective protein interaction networks. Interaction and\nexpression data are studied in the light of a detailed phylogenetic analysis.\nThe underlying network structure is incorporated explicitly into the\nstatistical analysis.\n The increased phylogenetic resolution, paired with high-quality interaction\ndata, allows us to resolve the way in which protein interaction network\nstructure and abundance of proteins affect the evolutionary rate. We find that\nexpression levels are better predictors of the evolutionary rate than a\nprotein\u0027s connectivity. Detailed analysis of the two organisms also shows that\nthe evolutionary rates of interacting proteins are not sufficiently similar to\nbe mutually predictive.\n It appears that meaningful inferences about the evolution of protein\ninteraction networks require comparative analysis of reasonably closely related\nspecies. The signature of protein evolution is shaped by a protein\u0027s abundance\nin the organism and its function and the biological process it is involved in.\nIts position in the interaction networks and its connectivity may modulate this\nbut they appear to have only minor influence on a protein\u0027s evolutionary rate.",
"arxiv_id": "q-bio/0503008",
"authors": [
"Ino Agrafioti",
"Jonathan Swire",
"James Abbott",
"Derek Huntley",
"Sarah Butcher",
"Michael P. H. Stumpf"
],
"categories": [
"q-bio.MN",
"cond-mat.dis-nn",
"q-bio.PE"
],
"journal_ref": "BMC Evolutionary Biology 2005, 5:23",
"title": "Comparative Analysis of the Saccharomyces cerevisiae and Caenorhabditis elegans Protein Interaction Network",
"url": "https://arxiv.org/abs/q-bio/0503008"
},
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