{
  "annotation_id": "1a9f5ad6-3ae7-4454-b220-91bc94a62693",
  "date_created": "2026-03-02T18:01:34.679000Z",
  "date_modified": "2026-03-02T18:01:34.679000Z",
  "file_hash": "c809f7ba407c5ffd74ae7c201b61fdea5131c75cece65cb6f7a19cdeef2864d5",
  "private": false,
  "record": {
    "abstract": "During the aging of the red-blood cell, or under conditions of extreme\nechinocytosis, membrane is shed from the cell plasma membrane in the form of\nnano-vesicles. We propose that this process is the result of the\nself-adaptation of the membrane surface area to the elastic stress imposed by\nthe spectrin cytoskeleton, via the local buckling of membrane under increasing\ncytoskeleton stiffness. This model introduces the concept of force balance as a\nregulatory process at the cell membrane, and quantitatively reproduces the rate\nof area loss in aging red-blood cells.",
    "arxiv_id": "q-bio/0608039",
    "authors": [
      "Pierre Sens",
      "Nir gov"
    ],
    "categories": [
      "q-bio.CB"
    ],
    "doi": "10.1103/PhysRevLett.98.018102",
    "title": "Force balance and membrane shedding at the Red Blood Cell surface",
    "url": "https://arxiv.org/abs/q-bio/0608039"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "51a4e77f-bb2f-48cd-b02c-fb766c019a9d",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}