{
  "annotation_id": "19bd15ab-af0a-4a7c-9d16-417ce5ef2aa9",
  "date_created": "2026-03-02T18:01:31.983000Z",
  "date_modified": "2026-03-02T18:01:31.983000Z",
  "file_hash": "d3e5fba6b3a48eefe44f9cff26a36747774b1337a174d822247c8c513ad4933c",
  "private": false,
  "record": {
    "abstract": "In this Letter, we extend the semiconservative quasispecies equations to\nincorporate imperfect DNA lesion repair. We study the equilibrium behavior of\nthis model in the limit of infinite sequence length and population size, using\na single-fitness-peak landscape for which the master genome can sustain a\nfinite number of lesions and remain viable. We provide a full analytical\ntreatment of the problem, providing a general mathematical framework as well as\nthe full solution for a particular class of fitness landscapes. Stochastic\nsimulations using finite sequence lengths and populations agree well with the\nanalytical results. Applications to biological systems are briefly discussed.",
    "arxiv_id": "q-bio/0406011",
    "authors": [
      "Yisroel Brumer",
      "Emmanuel Tannenbaum",
      "Eugene I. Shakhnovich"
    ],
    "categories": [
      "q-bio.BM",
      "q-bio.GN",
      "q-bio.PE"
    ],
    "title": "Imperfect DNA Repair and the Error Catastrophe",
    "url": "https://arxiv.org/abs/q-bio/0406011"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "ce48e3f8-9f10-4dbc-adcf-67663b9ae6f4",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}