{
  "annotation_id": "19461d3c-e3ed-4b27-a79e-2dbc56d84838",
  "date_created": "2026-03-02T18:00:57.059000Z",
  "date_modified": "2026-03-02T18:00:57.059000Z",
  "file_hash": "c54b79df37f550d66b431ad88e83c7a07a30a7b0c2df00643092cb3e641258df",
  "private": false,
  "record": {
    "abstract": "We have applied a simple statistical-mechanics G$\\bar{\\text{o}}$-like model\nto the analysis of the PIN1 WW domain, resorting to Mean Field and Monte Carlo\ntechniques to characterize its thermodynamics, and comparing the results with\nthe wealth of available experimental data. PIN1 WW domain is a 39-residues\nprotein fragment which folds on an antiparallel $\\beta$-sheet, thus\nrepresenting an interesting model system to study the behavior of these\nsecondary structure elements. Results show that the model correctly reproduces\nthe two-state behavior of the protein, and also the trends of the experimental\n$\\phi_T$-values. Moreover, there is a good agreement between Monte Carlo\nresults and the Mean-Field ones, which can be obtained with a substantially\nsmaller computational effort.",
    "arxiv_id": "physics/0501055",
    "authors": [
      "Pierpaolo Bruscolini",
      "Fabio Cecconi"
    ],
    "categories": [
      "physics.bio-ph",
      "cond-mat.soft"
    ],
    "title": "Analysis of PIN1 WW domain through a simple Statistical Mechanics Model",
    "url": "https://arxiv.org/abs/physics/0501055"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "ecbb46f1-eade-4b31-a718-a2c248f1a224",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}