{
  "annotation_id": "18df1962-a680-4a9e-a340-0920aae4a56f",
  "date_created": "2026-03-02T18:00:43.535000Z",
  "date_modified": "2026-03-02T18:00:43.535000Z",
  "file_hash": "d3753e45af207d7a9765a4824315bd105123bf449ec249b62bfc378c7147d525",
  "private": false,
  "record": {
    "abstract": "The interaction energies between the different types of bases of a single\nstrand of DNA molecule have been calculated. Using these original values of\nenergies the harmonic behavior of a number of base patterns of DNA has been\nstudied. In view of the great interest aroused by the discovery of the role of\nthe telomere segment of the DNA in the replication process and its possible\nlink with the aging process, we have investigated, with simple models, the\nharmonic behavior of the telomeric pattern of bases as well as the\nthermodynamic response in the biological system. With these results a\nconclusion on the probable role of the telomeric pattern on aging has also been\ndrawn. Here the calculated values of harmonic frequencies of the telomeric\npattern of bases and of other possible patterns show that the telomeric pattern\nis associated with the highest vibrational frequency among all patterns of base\ncombinations at the replication end of DNA. This seems to suggest that due to\nthe existing telomeric pattern being closest to the frequencies of the\nelectromagnetic radiation coming from sunlight, resonance of the telomeric\nfrequency with such radiation may be responsible for damage to the reproductive\nability of the cells and consequent aging and other problems. On the other hand\nin the last part of this work we have calculated the thermal vibrational\namplitudes of the telomeric pattern and other possible patterns which show that\nthe amplitude for the telomeric pattern is the least, and this suggests that\nthe telomeric pattern is more mechanically and thermally stable than other\npossible patterns in the biological environment against damage from ordinary\nheat and mechanical effects.",
    "arxiv_id": "physics/0301031",
    "authors": [
      "Md. Ashrafuzzaman",
      "Ahmed Shafee"
    ],
    "categories": [
      "physics.bio-ph",
      "physics.chem-ph",
      "q-bio"
    ],
    "title": "Investigation by physical methods of the possible role of telomeres in   DNA in aging process",
    "url": "https://arxiv.org/abs/physics/0301031"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "53bccedb-044e-4f82-8b4c-b39f4b3a44be",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}