dorsal/arxiv
View SchemaModelling and simulation of polycomb-dependent chromosomal interactions in drosophila
| Authors | S. Ritter, J. Odenheimer, D. W. Heermann, F. Bantignies, C. Grimaud, G. Cavalli |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0511008 |
| URL | https://arxiv.org/abs/q-bio/0511008 |
Abstract
The conditions of the chromosomes inside the nucleus in the Rabl configuration have been modelled as self-avoiding polymer chains under restraining conditions. To ensure that the chromosomes remain stretched out and lined up, we fixed their end points to two opposing walls. The numbers of segments $N$, the distances $d_1$ and $d_2$ between the fixpoints, and the wall-to-wall distance $z$ (as measured in segment lengths) determine an approximate value for the Kuhn segment length $k_l$. We have simulated the movement of the chromosomes using molecular dynamics to obtain the expected distance distribution between the genetic loci in the absence of further attractive or repulsive forces. A comparison to biological experiments on \textit{Drosophila Melanogaster} yields information on the parameters for our model. With the correct parameters it is possible to draw conclusions on the strength and range of the attraction that leads to pairing.
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"abstract": "The conditions of the chromosomes inside the nucleus in the Rabl\nconfiguration have been modelled as self-avoiding polymer chains under\nrestraining conditions. To ensure that the chromosomes remain stretched out and\nlined up, we fixed their end points to two opposing walls. The numbers of\nsegments $N$, the distances $d_1$ and $d_2$ between the fixpoints, and the\nwall-to-wall distance $z$ (as measured in segment lengths) determine an\napproximate value for the Kuhn segment length $k_l$. We have simulated the\nmovement of the chromosomes using molecular dynamics to obtain the expected\ndistance distribution between the genetic loci in the absence of further\nattractive or repulsive forces. A comparison to biological experiments on\n\\textit{Drosophila Melanogaster} yields information on the parameters for our\nmodel. With the correct parameters it is possible to draw conclusions on the\nstrength and range of the attraction that leads to pairing.",
"arxiv_id": "q-bio/0511008",
"authors": [
"S. Ritter",
"J. Odenheimer",
"D. W. Heermann",
"F. Bantignies",
"C. Grimaud",
"G. Cavalli"
],
"categories": [
"q-bio.SC"
],
"title": "Modelling and simulation of polycomb-dependent chromosomal interactions in drosophila",
"url": "https://arxiv.org/abs/q-bio/0511008"
},
"schema_id": "dorsal/arxiv",
"source": {
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"variant": "snapshot-2026-03-01",
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