dorsal/arxiv
View SchemaUpstream Plasticity and Downstream Robustness in Evolution of Molecular Networks
| Authors | Sergei Maslov, Kim Sneppen, Kasper Astrup Eriksen |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0310028 |
| URL | https://arxiv.org/abs/q-bio/0310028 |
Abstract
Evolving biomolecular networks have to combine the stability against perturbations with flexibility allowing their constituents to assume new roles in the cell. Gene duplication followed by functional divergence of associated proteins is a major force shaping molecular networks in living organisms. Recent availability of system-wide data for yeast S. Cerevisiae allow us to access the effects of gene duplication on robustness and plasticity of molecular networks. We demonstrate that the upstream transcriptional regulation of duplicated genes diverges fast, losing on average 4% of their common transcription factors for every 1% divergence of their amino acid sequences. In contrast, the set of physical interaction partners of their protein products changes much slower. The relative stability of downstream functions of duplicated genes, is further corroborated by their ability to substitute for each other in gene knockout experiments. We believe that the combination of the upstream plasticity and the downstream robustness is a general feature determining the evolvability of molecular networks.
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"abstract": "Evolving biomolecular networks have to combine the stability against\nperturbations with flexibility allowing their constituents to assume new roles\nin the cell. Gene duplication followed by functional divergence of associated\nproteins is a major force shaping molecular networks in living organisms.\nRecent availability of system-wide data for yeast S. Cerevisiae allow us to\naccess the effects of gene duplication on robustness and plasticity of\nmolecular networks. We demonstrate that the upstream transcriptional regulation\nof duplicated genes diverges fast, losing on average 4% of their common\ntranscription factors for every 1% divergence of their amino acid sequences. In\ncontrast, the set of physical interaction partners of their protein products\nchanges much slower. The relative stability of downstream functions of\nduplicated genes, is further corroborated by their ability to substitute for\neach other in gene knockout experiments. We believe that the combination of the\nupstream plasticity and the downstream robustness is a general feature\ndetermining the evolvability of molecular networks.",
"arxiv_id": "q-bio/0310028",
"authors": [
"Sergei Maslov",
"Kim Sneppen",
"Kasper Astrup Eriksen"
],
"categories": [
"q-bio.MN",
"q-bio.PE"
],
"title": "Upstream Plasticity and Downstream Robustness in Evolution of Molecular Networks",
"url": "https://arxiv.org/abs/q-bio/0310028"
},
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