dorsal/arxiv
View SchemaPhase Diagrams of Quasispecies Theory with Recombination and Horizontal Gene Transfer
| Authors | Jeong-Man Park, Michael W. Deem |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0612027 |
| URL | https://arxiv.org/abs/q-bio/0612027 |
| DOI | 10.1103/PhysRevLett.98.058101 |
Abstract
We consider how transfer of genetic information between individuals influences the phase diagram and mean fitness of both the Eigen and the parallel, or Crow-Kimura, models of evolution. In the absence of genetic transfer, these physical models of evolution consider the replication and point mutation of the genomes of independent individuals in a large population. A phase transition occurs, such that below a critical mutation rate an identifiable quasispecies forms. We generalize these models of quasispecies evolution to include horizontal gene transfer. We show how transfer of genetic information changes the phase diagram and mean fitness and introduces metastability in quasispecies theory, via an analytic field theoretic mapping.
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"abstract": "We consider how transfer of genetic information between individuals\ninfluences the phase diagram and mean fitness of both the Eigen and the\nparallel, or Crow-Kimura, models of evolution. In the absence of genetic\ntransfer, these physical models of evolution consider the replication and point\nmutation of the genomes of independent individuals in a large population. A\nphase transition occurs, such that below a critical mutation rate an\nidentifiable quasispecies forms. We generalize these models of quasispecies\nevolution to include horizontal gene transfer. We show how transfer of genetic\ninformation changes the phase diagram and mean fitness and introduces\nmetastability in quasispecies theory, via an analytic field theoretic mapping.",
"arxiv_id": "q-bio/0612027",
"authors": [
"Jeong-Man Park",
"Michael W. Deem"
],
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"q-bio.PE"
],
"doi": "10.1103/PhysRevLett.98.058101",
"title": "Phase Diagrams of Quasispecies Theory with Recombination and Horizontal Gene Transfer",
"url": "https://arxiv.org/abs/q-bio/0612027"
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