dorsal/arxiv
View SchemaSensitivity Analysis of Stoichiometric Networks: An Extension of Metabolic Control Analysis to Non-equilibrium Trajectories
| Authors | Brian P. Ingalls, Herbert M. Sauro |
|---|---|
| Categories | |
| ArXiv ID | physics/0206075 |
| URL | https://arxiv.org/abs/physics/0206075 |
Abstract
A sensitivity analysis of general stoichiometric networks is considered. The results are presented as a generalization of Metabolic Control Analysis, which has been concerned primarily with system sensitivities at steady state. An expression for time-varying sensitivity coefficients is given, and the Summation and Connectivity Theorems are generalized. The results are compared to previous treatments. The analysis is accompanied by a discussion of the computation of the sensitivity coefficients and an application to a model of phototransduction.
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"abstract": "A sensitivity analysis of general stoichiometric networks is considered. The\nresults are presented as a generalization of Metabolic Control Analysis, which\nhas been concerned primarily with system sensitivities at steady state. An\nexpression for time-varying sensitivity coefficients is given, and the\nSummation and Connectivity Theorems are generalized. The results are compared\nto previous treatments. The analysis is accompanied by a discussion of the\ncomputation of the sensitivity coefficients and an application to a model of\nphototransduction.",
"arxiv_id": "physics/0206075",
"authors": [
"Brian P. Ingalls",
"Herbert M. Sauro"
],
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"physics.bio-ph",
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"title": "Sensitivity Analysis of Stoichiometric Networks: An Extension of Metabolic Control Analysis to Non-equilibrium Trajectories",
"url": "https://arxiv.org/abs/physics/0206075"
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