dorsal/arxiv
View SchemaDynamics of force-induced DNA slippage
| Authors | Richard A. Neher, Ulrich Gerland |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0407017 |
| URL | https://arxiv.org/abs/q-bio/0407017 |
| DOI | 10.1103/PhysRevLett.93.198102 |
Abstract
We study the basepairing dynamics of DNA with repetitive sequences where local strand slippage can create, annihilate, and move bulge loops. Using an explicit theoretical model, we find a rich dynamical behavior as a function of an applied shear force f: reptation-like dynamics at f=f_c with a rupture time scaling as N^3 with its length N, drift-diffusion dynamics for f_c < f < f^*, and a dynamical transition to an unraveling mode of strand separation at f = f^*. We predict a viscoelastic behavior for periodic DNA with time and force scales that can be programmed into its sequence.
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"abstract": "We study the basepairing dynamics of DNA with repetitive sequences where\nlocal strand slippage can create, annihilate, and move bulge loops. Using an\nexplicit theoretical model, we find a rich dynamical behavior as a function of\nan applied shear force f: reptation-like dynamics at f=f_c with a rupture time\nscaling as N^3 with its length N, drift-diffusion dynamics for f_c \u003c f \u003c f^*,\nand a dynamical transition to an unraveling mode of strand separation at f =\nf^*. We predict a viscoelastic behavior for periodic DNA with time and force\nscales that can be programmed into its sequence.",
"arxiv_id": "q-bio/0407017",
"authors": [
"Richard A. Neher",
"Ulrich Gerland"
],
"categories": [
"q-bio.BM",
"cond-mat.soft"
],
"doi": "10.1103/PhysRevLett.93.198102",
"title": "Dynamics of force-induced DNA slippage",
"url": "https://arxiv.org/abs/q-bio/0407017"
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