dorsal/arxiv
View SchemaThe Effects of EGF-Receptor Density on Multiscale Tumor Growth Patterns
| Authors | Chaitanya A. Athale, Thomas S. Deisboeck |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0502002 |
| URL | https://arxiv.org/abs/q-bio/0502002 |
Abstract
We studied the effects of epidermal growth factor receptor (EGFR) density on tumor growth dynamics, both on the sub- and the multi-cellular level using our previously developed model. This algorithm simulates the growth of a brain tumor using a multi-scale two-dimensional agent-based approach with an integrated transforming growth factor alpha (TGFalpha) induced EGFR-gene-protein interaction network. The results confirm that increasing cell receptor density correlates with an acceleration of the tumor system's spatio-temporal expansion dynamics. This multicellular behavior cannot be explained solely on the basis of spatial sub-cellular dynamics, which remain qualitatively similar amongst the three glioma cell lines investigated here in silico. Rather, we find that cells with higher EGFR density show an early increase in the phenotypic switching activity between proliferative and migratory traits, linked to a higher level of initial auto-stimulation by the PLCgamma-mediated TGFalpha-EGFR autocrine network. This indicates a more active protein level interaction in these chemotactically acting tumor systems and supports the role of post-translational regulation for the implemented EGFR pathway. Implications of these results for experimental cancer research are discussed.
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"abstract": "We studied the effects of epidermal growth factor receptor (EGFR) density on\ntumor growth dynamics, both on the sub- and the multi-cellular level using our\npreviously developed model. This algorithm simulates the growth of a brain\ntumor using a multi-scale two-dimensional agent-based approach with an\nintegrated transforming growth factor alpha (TGFalpha) induced\nEGFR-gene-protein interaction network. The results confirm that increasing cell\nreceptor density correlates with an acceleration of the tumor system\u0027s\nspatio-temporal expansion dynamics. This multicellular behavior cannot be\nexplained solely on the basis of spatial sub-cellular dynamics, which remain\nqualitatively similar amongst the three glioma cell lines investigated here in\nsilico. Rather, we find that cells with higher EGFR density show an early\nincrease in the phenotypic switching activity between proliferative and\nmigratory traits, linked to a higher level of initial auto-stimulation by the\nPLCgamma-mediated TGFalpha-EGFR autocrine network. This indicates a more active\nprotein level interaction in these chemotactically acting tumor systems and\nsupports the role of post-translational regulation for the implemented EGFR\npathway. Implications of these results for experimental cancer research are\ndiscussed.",
"arxiv_id": "q-bio/0502002",
"authors": [
"Chaitanya A. Athale",
"Thomas S. Deisboeck"
],
"categories": [
"q-bio.CB",
"q-bio.MN",
"q-bio.OT"
],
"title": "The Effects of EGF-Receptor Density on Multiscale Tumor Growth Patterns",
"url": "https://arxiv.org/abs/q-bio/0502002"
},
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