{
  "annotation_id": "11c5015e-ebe0-43a6-a94c-f27d12ece636",
  "date_created": "2026-03-02T18:01:35.302000Z",
  "date_modified": "2026-03-02T18:01:35.302000Z",
  "file_hash": "24a965c3d335344c96651579d0af9ee79ef9f4e221629481b9d7ac5be92db13e",
  "private": false,
  "record": {
    "abstract": "We model the interaction between the immune system and tumor cells including\na time delay to simulate the time needed by the latter to develop a chemical\nand cell mediated response to the presence of the tumor. The results are\ncompared with those of a previous paper, concluding that the delay introduces\nnew instabilities in the system leading to an uncontrolable growth of the\ntumour. Then a cytokine based periodic immunotherapy treatment is included in\nthe model and the effects of its dossage are studied for the case of a weak\nimmune system and a growing tumour. We find the existence of metastable states\n(that may last for tens of years) induced by the treatment, and also of\npotentially adverse effects of the dossage frequency on the stabilization of\nthe tumour. These two effects depend on the delay, the cytokine dose burden and\nother parameters considered in the model.",
    "arxiv_id": "q-bio/0604008",
    "authors": [
      "D. Rodriguez-Perez",
      "Oscar Sotolongo-Grau",
      "Ramon Espinosa Riquelme",
      "Oscar Sotolongo-Costa",
      "J. Antonio Santos Miranda",
      "J. C. Antoranz"
    ],
    "categories": [
      "q-bio.TO"
    ],
    "title": "Tumors under periodic therapy -- Role of the immune response time delay",
    "url": "https://arxiv.org/abs/q-bio/0604008"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "ab4e33de-8710-418c-b430-450d72a742a7",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}