{
  "annotation_id": "11458a10-4f90-4773-b103-c1b1be335e2a",
  "date_created": "2026-03-02T18:01:35.433000Z",
  "date_modified": "2026-03-02T18:01:35.433000Z",
  "file_hash": "b475709f818bc2be0c55754a1b3e588b6eb5e47b12ceebc46643065af98b5bab",
  "private": false,
  "record": {
    "abstract": "The development of new techniques to quantitatively measure gene expression\nin cells has shed light on a number of systems that display oscillations in\nprotein concentration. Here we review the different mechanisms which can\nproduce oscillations in gene expression or protein concentration, using a\nframework of simple mathematical models. We focus on three eukaryotic genetic\nregulatory networks which show \"ultradian\" oscillations, with time period of\nthe order of hours, and involve, respectively, proteins important for\ndevelopment (Hes1), apoptosis (p53) and immune response (NFkB). We argue that\nunderlying all three is a common design consisting of a negative feedback loop\nwith time delay which is responsible for the oscillatory behaviour.",
    "arxiv_id": "q-bio/0703047",
    "authors": [
      "G. Tiana",
      "S. Krishna",
      "S. Pigolotti",
      "M. H. Jensen",
      "K. Sneppen"
    ],
    "categories": [
      "q-bio.MN"
    ],
    "doi": "10.1088/1478-3975/4/2/R01",
    "title": "Oscillations and temporal signalling in cells",
    "url": "https://arxiv.org/abs/q-bio/0703047"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "9118d7f5-21ab-4c45-a5a4-001d1892bcd6",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}