dorsal/arxiv
View SchemaEvolutionary conservation of motif constituents within the yeast protein interaction network
| Authors | S. Wuchty, Z. N. Oltvai, A. -L. Barabasi |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0310024 |
| URL | https://arxiv.org/abs/q-bio/0310024 |
| Journal | Nature Genetics, 35(2), 176-179, (2003) |
Abstract
Understanding why some cellular components are conserved across species, while others evolve rapidly is a key question of modern biology. Here we demonstrate that in S. cerevisiae proteins organized in cohesive patterns of interactions are conserved to a significantly higher degree than those that do not participate in such motifs. We find that the conservation of proteins within distinct topological motifs correlates with the motif's inter-connectedness and function and also depends on the structure of the overall interactome topology. These findings indicate that motifs may represent evolutionary conserved topological units of cellular networks molded in accordance with the specific biological function in which they participate.
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"abstract": "Understanding why some cellular components are conserved across species,\nwhile others evolve rapidly is a key question of modern biology. Here we\ndemonstrate that in S. cerevisiae proteins organized in cohesive patterns of\ninteractions are conserved to a significantly higher degree than those that do\nnot participate in such motifs. We find that the conservation of proteins\nwithin distinct topological motifs correlates with the motif\u0027s\ninter-connectedness and function and also depends on the structure of the\noverall interactome topology. These findings indicate that motifs may represent\nevolutionary conserved topological units of cellular networks molded in\naccordance with the specific biological function in which they participate.",
"arxiv_id": "q-bio/0310024",
"authors": [
"S. Wuchty",
"Z. N. Oltvai",
"A. -L. Barabasi"
],
"categories": [
"q-bio.GN",
"cond-mat"
],
"journal_ref": "Nature Genetics, 35(2), 176-179, (2003)",
"title": "Evolutionary conservation of motif constituents within the yeast protein interaction network",
"url": "https://arxiv.org/abs/q-bio/0310024"
},
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