{
  "annotation_id": "0dc0527a-d1b4-4950-84c9-b4570abc859c",
  "date_created": "2026-03-02T18:01:35.777000Z",
  "date_modified": "2026-03-02T18:01:35.777000Z",
  "file_hash": "2e4a3cdaa8b2a3f491d4d49d48eadea40091a3627ead512d62fcea1e528f54b3",
  "private": false,
  "record": {
    "abstract": "Bistability is a major mechanism for cellular decision making and usually\nresults from positive feedback in biochemical control systems. Here we show\ntheoretically that bistability between unbound and bound states of adhesion\nclusters results from positive feedback mediated by structural rather than\nbiochemical processes, namely by receptor-ligand dissociation and association\ndynamics which depend non-linearly on mechanical force and receptor-ligand\nseparation. For small cell-matrix adhesions, we find rapid switching between\nunbound and bound states, which in the initial stages of adhesion allows the\ncell to explore its environment through many transient adhesions.",
    "arxiv_id": "q-bio/0608007",
    "authors": [
      "T. Erdmann",
      "U. S. Schwarz"
    ],
    "categories": [
      "q-bio.SC",
      "q-bio.BM"
    ],
    "doi": "10.1529/biophysj.106.090209",
    "journal_ref": "Biophys. J., 91:L60-L62, 2006",
    "title": "Bistability of cell-matrix adhesions resulting from non-linear   receptor-ligand dynamics",
    "url": "https://arxiv.org/abs/q-bio/0608007"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "9cc9420a-b9bd-45af-9148-c5854cae6ec1",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}