{
  "annotation_id": "0bbcd242-e905-41b3-aa18-0c1a0b9fdf63",
  "date_created": "2026-03-02T18:01:32.164000Z",
  "date_modified": "2026-03-02T18:01:32.164000Z",
  "file_hash": "e4ff12e467c8d84dc43e9b1e78d588c652b36dbce5c4ce5d0773740369cbf499",
  "private": false,
  "record": {
    "abstract": "The so-called Mixed Feedback Loop (MFL) is a small two-gene network where\nprotein A regulates the transcription of protein B and the two proteins form a\nheterodimer. It has been found to be statistically over-represented in\nstatistical analyses of gene and protein interaction databases and to lie at\nthe core of several computer-generated genetic networks. Here, we propose and\nmathematically study a model of the MFL and show that, by itself, it can serve\nboth as a bistable switch and as a clock (an oscillator) depending on kinetic\nparameters. The MFL phase diagram as well as a detailed description of the\nnonlinear oscillation regime are presented and some biological examples are\ndiscussed. The results emphasize the role of protein interactions in the\nfunction of genetic modules and the usefulness of modelling RNA dynamics\nexplicitly.",
    "arxiv_id": "q-bio/0507044",
    "authors": [
      "Paul Francois",
      "Vincent Hakim"
    ],
    "categories": [
      "q-bio.MN",
      "q-bio.OT"
    ],
    "doi": "10.1103/PhysRevE.72.031908",
    "title": "A core genetic module : the Mixed Feedback Loop",
    "url": "https://arxiv.org/abs/q-bio/0507044"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "64e399d0-f20b-424d-8289-77e6638eda7d",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}