dorsal/arxiv
View SchemaMultiprotein DNA looping
| Authors | Jose M. G. Vilar, Leonor Saiz |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0603020 |
| URL | https://arxiv.org/abs/q-bio/0603020 |
| DOI | 10.1103/PhysRevLett.96.238103 |
| Journal | Phys. Rev. Lett. 96, 238103 (2006) |
Abstract
DNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switch-like transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance.
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"abstract": "DNA looping plays a fundamental role in a wide variety of biological\nprocesses, providing the backbone for long range interactions on DNA. Here we\ndevelop the first model for DNA looping by an arbitrarily large number of\nproteins and solve it analytically in the case of identical binding. We uncover\na switch-like transition between looped and unlooped phases and identify the\nkey parameters that control this transition. Our results establish the basis\nfor the quantitative understanding of fundamental cellular processes like DNA\nrecombination, gene silencing, and telomere maintenance.",
"arxiv_id": "q-bio/0603020",
"authors": [
"Jose M. G. Vilar",
"Leonor Saiz"
],
"categories": [
"q-bio.SC",
"cond-mat.stat-mech",
"physics.bio-ph",
"q-bio.BM"
],
"doi": "10.1103/PhysRevLett.96.238103",
"journal_ref": "Phys. Rev. Lett. 96, 238103 (2006)",
"title": "Multiprotein DNA looping",
"url": "https://arxiv.org/abs/q-bio/0603020"
},
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