{
  "annotation_id": "0a6e9b27-6ecb-41b0-8d16-9943cfa3f384",
  "date_created": "2026-03-02T18:01:34.825000Z",
  "date_modified": "2026-03-02T18:01:34.825000Z",
  "file_hash": "3565b817b81f30dc06051a6e276d6c09596b308d20c87421c7d781a1dac641e1",
  "private": false,
  "record": {
    "abstract": "In this paper we consider the evolution of the HIV infection under a highly\neffective treatment based on a combination of RTI and/or PI drugs. This is\nusually modelled with a set of ODEs where the drug efficacy is a constant. In\nthis paper we consider the treatment efficacy as a dynamic variable which\nevolves during the treatment. To model the dynamics of the drug efficacy we use\nan evolutive type assumption. The resulting set of ODEs are able to reproduce\nthe typical pattern of the illness evolution under treatment: a period of\nremission, which can last several years, followed by a progressive\nrecrudescence and a viral rebound.",
    "arxiv_id": "q-bio/0703058",
    "authors": [
      "G. Della Rocca",
      "M. Sammartino",
      "L. Seta"
    ],
    "categories": [
      "q-bio.PE",
      "q-bio.QM"
    ],
    "journal_ref": "Ricerche di Matematica, 54(1), 313-327, 2005",
    "title": "A mathematical model for the therapy of the HIV infection",
    "url": "https://arxiv.org/abs/q-bio/0703058"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "9d6ae769-49af-4c31-a0de-04471a979d2c",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}