{
  "annotation_id": "0a3cce65-da48-4207-9b0c-2369d215f8a6",
  "date_created": "2026-03-02T18:01:35.043000Z",
  "date_modified": "2026-03-02T18:01:35.043000Z",
  "file_hash": "d942b583246290ef2dc1fc1f54b9bb6c59e46f3ebca66f669dd77374c65c9eba",
  "private": false,
  "record": {
    "abstract": "Changes in gene expression occurring during differentiation of human\nmonocytes into dendritic cells were studied at the RNA and protein levels.\nThese studies showed the induction of several gene classes corresponding to\nvarious biological functions. These functions encompass antigen processing and\npresentation, cytoskeleton, cell signalling and signal transduction, but also\nan increase in mitochondrial function and in the protein synthesis machinery,\nincluding some, but not all, chaperones. These changes put in perspective the\nevents occurring during this differentiation process. On a more technical\npoint, it appears that the studies carried out at the RNA and protein levels\nare highly complementary.",
    "arxiv_id": "q-bio/0612006",
    "authors": [
      "C. Ang\u00e9nieux",
      "D. Fricker",
      "J. M. Strub",
      "S. Luche",
      "H. Bausinger",
      "J. P. Cazenave",
      "A. Van Dorsselaer",
      "D. Hanau",
      "H. de la Salle",
      "T. Rabilloud"
    ],
    "categories": [
      "q-bio.GN"
    ],
    "doi": "10.1007/s101420100037",
    "journal_ref": "Funct Integr Genomics 1 (09/2001) 323-9",
    "title": "Gene induction during differentiation of human monocytes into dendritic   cells: an integrated study at the RNA and protein levels",
    "url": "https://arxiv.org/abs/q-bio/0612006"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "fcf62bf9-8651-432e-a6ab-3076a658bb8d",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}