dorsal/arxiv
View SchemaPrinciples of microRNA regulation of a human cellular signaling network
| Authors | Qinghua Cui, Zhenbao Yu, Enrico O. Purisima, Edwin Wang |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0612034 |
| URL | https://arxiv.org/abs/q-bio/0612034 |
| DOI | 10.1038/msb4100089 |
| Journal | Molecular Systems Biology, 2:46, 2006 |
Abstract
MicroRNAs (miRNAs) are endogenous 22-nucleotide RNAs, which suppress gene expression by selectively binding to the 3-noncoding region of specific message RNAs through base-pairing. Given the diversity and abundance of miRNA targets, miRNAs appear to functionally interact with various components of many cellular networks. By analyzing the interactions between miRNAs and a human cellular signaling network, we found that miRNAs predominantly target positive regulatory motifs, highly connected scaffolds and most downstream network components such as signaling transcription factors, but less frequently target negative regulatory motifs, common components of basic cellular machines and most upstream network components such as ligands. In addition, when an adaptor has potential to recruit more downstream components, these components are more frequently targeted by miRNAs. This work uncovers the principles of miRNA regulation of signal transduction networks and implies a potential function of miRNAs for facilitating robust transitions of cellular response to extracellular signals and maintaining cellular homeostasis.
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"abstract": "MicroRNAs (miRNAs) are endogenous 22-nucleotide RNAs, which suppress gene\nexpression by selectively binding to the 3-noncoding region of specific message\nRNAs through base-pairing. Given the diversity and abundance of miRNA targets,\nmiRNAs appear to functionally interact with various components of many cellular\nnetworks. By analyzing the interactions between miRNAs and a human cellular\nsignaling network, we found that miRNAs predominantly target positive\nregulatory motifs, highly connected scaffolds and most downstream network\ncomponents such as signaling transcription factors, but less frequently target\nnegative regulatory motifs, common components of basic cellular machines and\nmost upstream network components such as ligands. In addition, when an adaptor\nhas potential to recruit more downstream components, these components are more\nfrequently targeted by miRNAs. This work uncovers the principles of miRNA\nregulation of signal transduction networks and implies a potential function of\nmiRNAs for facilitating robust transitions of cellular response to\nextracellular signals and maintaining cellular homeostasis.",
"arxiv_id": "q-bio/0612034",
"authors": [
"Qinghua Cui",
"Zhenbao Yu",
"Enrico O. Purisima",
"Edwin Wang"
],
"categories": [
"q-bio.MN",
"q-bio.GN"
],
"doi": "10.1038/msb4100089",
"journal_ref": "Molecular Systems Biology, 2:46, 2006",
"title": "Principles of microRNA regulation of a human cellular signaling network",
"url": "https://arxiv.org/abs/q-bio/0612034"
},
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