{
  "annotation_id": "06445fbe-700e-4a72-8121-b6208d836964",
  "date_created": "2026-03-02T18:01:31.667000Z",
  "date_modified": "2026-03-02T18:01:31.667000Z",
  "file_hash": "22c0874559a9f6625a620563ac29a7b56e0b55a9d1d8fd34f424538856ca0342",
  "private": false,
  "record": {
    "abstract": "We study a role of EphB receptors and their ligand ephrin-B1 in\ndorsal-ventral retinotopic mapping. Earlier studies suggested that ephrin-B1\nacts as an attractant for EphB expressing axons. We address the results of the\nrecent experiment in chick tectum (McLaughlin et al., 2003b) in which axons of\nretinal ganglion cells were shown to be repelled by high ephrin-B1 density.\nThus it was proposed that ephrin-B1 might act as both attractant and repellent.\nWe show that the same axonal behavior may follow from attraction to ephrin-B1\ndensity and axonal competition for space. Therefore, we show how apparent\nrepulsive interaction can be induced by a combination of attraction to the\ntarget and competitive interactions between axons. We suggest an experimental\ntest that may distinguish repulsive interaction with the target from repulsion\ninduced by attraction and competition.",
    "arxiv_id": "q-bio/0403013",
    "authors": [
      "Dmitry N. Tsigankov",
      "Alexei A. Koulakov"
    ],
    "categories": [
      "q-bio.NC",
      "q-bio.QM"
    ],
    "title": "Can repulsion be induced by attraction: a role of ephrin-B1 in   retinotectal mapping?",
    "url": "https://arxiv.org/abs/q-bio/0403013"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "e87a0506-46f2-4f0e-be1b-ff7f49dc4b8f",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}