dorsal/arxiv
View SchemaMechanism of Anesthetic Action: Oxygen Pathway Perturbation Hypothesis
| Authors | Huping Hu, Maoxin Wu |
|---|---|
| Categories | |
| ArXiv ID | physics/0101083 |
| URL | https://arxiv.org/abs/physics/0101083 |
| Journal | Medical Hypothese (2001) 57(5): 619-627. |
Abstract
Although more than 150 years have past since the discovery of general anesthetics, how they precisely work remains a mystery. We propose a novel unitary mechanism of general anesthesia verifiable by experiments. In the proposed mechanism, general anesthetics perturb oxygen pathways in both membranes and oxygen-utilizing proteins such that the availabilities of oxygen to its sites of utilization are reduced which in turn triggers cascading cellular responses through oxygen-sensing mechanisms resulting in general anesthesia. Despite the general assumption that cell membranes are readily permeable to oxygen, exiting publications indicate that these membranes are plausible oxygen transport barriers. The present hypothesis provides a unified framework for explaining phenomena associated with general anesthesia and experimental results on the actions of general anesthetics. If verified by experiments, the proposed mechanism also has other significant medical and biological implications.
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"abstract": "Although more than 150 years have past since the discovery of general\nanesthetics, how they precisely work remains a mystery. We propose a novel\nunitary mechanism of general anesthesia verifiable by experiments. In the\nproposed mechanism, general anesthetics perturb oxygen pathways in both\nmembranes and oxygen-utilizing proteins such that the availabilities of oxygen\nto its sites of utilization are reduced which in turn triggers cascading\ncellular responses through oxygen-sensing mechanisms resulting in general\nanesthesia. Despite the general assumption that cell membranes are readily\npermeable to oxygen, exiting publications indicate that these membranes are\nplausible oxygen transport barriers. The present hypothesis provides a unified\nframework for explaining phenomena associated with general anesthesia and\nexperimental results on the actions of general anesthetics. If verified by\nexperiments, the proposed mechanism also has other significant medical and\nbiological implications.",
"arxiv_id": "physics/0101083",
"authors": [
"Huping Hu",
"Maoxin Wu"
],
"categories": [
"physics.med-ph",
"physics.bio-ph",
"q-bio"
],
"journal_ref": "Medical Hypothese (2001) 57(5): 619-627.",
"title": "Mechanism of Anesthetic Action: Oxygen Pathway Perturbation Hypothesis",
"url": "https://arxiv.org/abs/physics/0101083"
},
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