{
  "annotation_id": "0530ea0b-de29-488e-830e-4c28c40ac03a",
  "date_created": "2026-03-02T18:01:32.291000Z",
  "date_modified": "2026-03-02T18:01:32.291000Z",
  "file_hash": "af92f32d206aa9d7b050d652b70001785c15fead87e97341b571098663e01183",
  "private": false,
  "record": {
    "abstract": "A variety of oscillations are observed in pancreatic islets.We establish a\nmodel, incorporating two oscillatory systems of different time scales: One is\nthe well-known bursting model in pancreatic beta-cells and the other is the\nglucose-insulin feedback model which considers direct and indirect feedback of\nsecreted insulin. These two are coupled to interact with each other in the\ncombined model, and two basic assumptions are made on the basis of biological\nobservations: The conductance g_{K(ATP)} for the ATP-dependent potassium\ncurrent is a decreasing function of the glucose concentration whereas the\ninsulin secretion rate is given by a function of the intracellular calcium\nconcentration. Obtained via extensive numerical simulations are complex\noscillations including clusters of bursts, slow and fast calcium oscillations,\nand so on. We also consider how the intracellular glucose concentration depends\nupon the extracellular glucose concentration, and examine the inhibitory\neffects of insulin.",
    "arxiv_id": "q-bio/0509029",
    "authors": [
      "H. Kang",
      "J. Jo",
      "H. J. Kim",
      "M. Y. Choi",
      "S. W. Rhee",
      "D. S. Koh"
    ],
    "categories": [
      "q-bio.CB",
      "cond-mat.other",
      "q-bio.QM"
    ],
    "doi": "10.1103/PhysRevE.72.051905",
    "title": "Glucose metabolism and oscillatory behavior of pancreatic islets",
    "url": "https://arxiv.org/abs/q-bio/0509029"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "436b6bde-9d29-45df-87fb-9dd3ecebcdab",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}