dorsal/arxiv
View SchemaThe Yeast Cell-Cycle Network Is Robustly Designed
| Authors | Fangting Li, Tao Long, Ying Lu, Qi Ouyang, Chao Tang |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0310010 |
| URL | https://arxiv.org/abs/q-bio/0310010 |
| DOI | 10.1073/pnas.0305937101 |
| Journal | PNAS 101, 4781 (2004). |
Abstract
The interactions between proteins, DNA, and RNA in living cells constitute molecular networks that govern various cellular functions. To investigate the global dynamical properties and stabilities of such networks, we studied the cell-cycle regulatory network of the budding yeast. With the use of a simple dynamical model, it was demonstrated that the cell-cycle network is extremely stable and robust for its function. The biological stationary state--the G1 state--is a global attractor of the dynamics. The biological pathway--the cell-cycle sequence of protein states--is a globally attracting trajectory of the dynamics. These properties are largely preserved with respect to small perturbations to the network. These results suggest that cellular regulatory networks are robustly designed for their functions.
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"abstract": "The interactions between proteins, DNA, and RNA in living cells constitute\nmolecular networks that govern various cellular functions. To investigate the\nglobal dynamical properties and stabilities of such networks, we studied the\ncell-cycle regulatory network of the budding yeast. With the use of a simple\ndynamical model, it was demonstrated that the cell-cycle network is extremely\nstable and robust for its function. The biological stationary state--the G1\nstate--is a global attractor of the dynamics. The biological pathway--the\ncell-cycle sequence of protein states--is a globally attracting trajectory of\nthe dynamics. These properties are largely preserved with respect to small\nperturbations to the network. These results suggest that cellular regulatory\nnetworks are robustly designed for their functions.",
"arxiv_id": "q-bio/0310010",
"authors": [
"Fangting Li",
"Tao Long",
"Ying Lu",
"Qi Ouyang",
"Chao Tang"
],
"categories": [
"q-bio.MN",
"cond-mat.stat-mech",
"q-bio.CB"
],
"doi": "10.1073/pnas.0305937101",
"journal_ref": "PNAS 101, 4781 (2004).",
"title": "The Yeast Cell-Cycle Network Is Robustly Designed",
"url": "https://arxiv.org/abs/q-bio/0310010"
},
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