{
  "annotation_id": "045842eb-74a1-4fa4-b3fb-74cd513367de",
  "date_created": "2026-02-17T05:53:12.061000Z",
  "date_modified": "2026-02-17T05:53:12.061000Z",
  "file_hash": "f3c3332a6764a9f1e3a2bbd69995965b5dc593a80c9a1adce76fb0d960de3459",
  "private": false,
  "record": {
    "abstract": "In this study, we develop and analyze a deterministic two-strain host-vector model for dengue transmission that incorporates key immuno-epidemiological mechanisms, including temporary cross-immunity, antibody-dependent enhancement (ADE), disease-induced mortality during secondary infections, and explicit vector co-infection. The human population is divided into compartments for primary and secondary infections, while the mosquito population includes single- and co-infected classes. ADE is modeled through distinct primary ($\\alpha$) and secondary ($\\sigma$) transmission rates. Using the next-generation matrix method, we derive the basic reproduction number $R_0$ and establish the local stability of the disease-free equilibrium for $R_0 \u003c 1$. Analytical results show that one-strain endemic equilibria lose stability under ADE conditions ($\\sigma \u003e \\alpha$), allowing invasion by a heterologous strain. Employing center-manifold theory and numerical continuation (COCO), we demonstrate the occurrence of backward bifurcation, bistability between disease-free and endemic states, and Hopf-induced oscillations. Numerical simulations confirm transitions among disease-free, endemic, and periodic regimes as key parameters vary. The model highlights how ADE, waning cross-immunity, and vector co-infection interact to generate complex dengue dynamics and provides insights useful for designing effective control and vaccination strategies in dengue-endemic regions.",
    "arxiv_id": "2601.07403",
    "authors": [
      "Burcu G\u00fcrb\u00fcz",
      "Ayt\u00fcl G\u00f6k\u00e7e",
      "Joseph P\u00e1ez Ch\u00e1vez",
      "Thomas G\u00f6tz"
    ],
    "categories": [
      "math.DS",
      "q-bio.PE"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "title": "Modeling and analysis of a novel two-strain dengue epidemics model considering secondary infections with increased mortality",
    "url": "https://arxiv.org/abs/2601.07403",
    "version": "v1"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "e00af98b-e6b1-483c-b1ff-5a6208aad556",
    "id": "arXiv Dataset",
    "type": "Model",
    "variant": "snapshot-2026-01-17",
    "version": "0.1.0"
  },
  "user_id": 1000002
}