dorsal/arxiv
View SchemaGenetic Toggle Switch Without Cooperative Binding
| Authors | Azi Lipshtat, Adiel Loinger, Nathalie Q. Balaban, Ofer Biham |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0603026 |
| URL | https://arxiv.org/abs/q-bio/0603026 |
| DOI | 10.1103/PhysRevLett.96.188101 |
Abstract
Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.
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"abstract": "Genetic switch systems with mutual repression of two transcription factors\nare studied using deterministic and stochastic methods. Numerous studies have\nconcluded that cooperative binding is a necessary condition for the emergence\nof bistability in these systems. Here we show that for a range of biologically\nrelevant conditions, a suitable combination of network structure and stochastic\neffects gives rise to bistability even without cooperative binding.",
"arxiv_id": "q-bio/0603026",
"authors": [
"Azi Lipshtat",
"Adiel Loinger",
"Nathalie Q. Balaban",
"Ofer Biham"
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"q-bio.MN"
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"doi": "10.1103/PhysRevLett.96.188101",
"title": "Genetic Toggle Switch Without Cooperative Binding",
"url": "https://arxiv.org/abs/q-bio/0603026"
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