dorsal/arxiv
View SchemaAre structural biases at protein termini a signature of vectorial folding?
| Authors | Alessandro Laio, Cristian Micheletti |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0510038 |
| URL | https://arxiv.org/abs/q-bio/0510038 |
Abstract
Experimental investigations of the biosynthesis of a number of proteins have pointed out that part of the native structure can be acquired already during translation. We carried out a comprehensive statistical analysis of some average structural properties of proteins that have been put forward as possible signatures of this progressive buildup process. Contrary to a widespread belief, it is found that there is no major propensity of the amino acids to form contacts with residues that are closer to the N terminus. Moreover, it is found that the C terminus is significantly more compact and locally-organized than the N one. Also this bias, though, is unlikely to be related to vectorial effects, since it correlates with subtle differences in the primary sequence. These findings indicate that even if proteins aquire their structure vectorially no signature of this seems to be detectable in their average structural properties.
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"abstract": "Experimental investigations of the biosynthesis of a number of proteins have\npointed out that part of the native structure can be acquired already during\ntranslation. We carried out a comprehensive statistical analysis of some\naverage structural properties of proteins that have been put forward as\npossible signatures of this progressive buildup process. Contrary to a\nwidespread belief, it is found that there is no major propensity of the amino\nacids to form contacts with residues that are closer to the N terminus.\nMoreover, it is found that the C terminus is significantly more compact and\nlocally-organized than the N one. Also this bias, though, is unlikely to be\nrelated to vectorial effects, since it correlates with subtle differences in\nthe primary sequence. These findings indicate that even if proteins aquire\ntheir structure vectorially no signature of this seems to be detectable in\ntheir average structural properties.",
"arxiv_id": "q-bio/0510038",
"authors": [
"Alessandro Laio",
"Cristian Micheletti"
],
"categories": [
"q-bio.BM"
],
"title": "Are structural biases at protein termini a signature of vectorial folding?",
"url": "https://arxiv.org/abs/q-bio/0510038"
},
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