dorsal/arxiv
View SchemaSequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation
| Authors | Vincent Lemaire, Chiu Fan Lee, Jinzhi Lei, Raphael Metivier, Leon Glass |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0605049 |
| URL | https://arxiv.org/abs/q-bio/0605049 |
| DOI | 10.1103/PhysRevLett.96.198102 |
| Journal | Phys. Rev. Lett. 96, 198102 (2006) |
Abstract
In human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number of sequential reactions represented by linear kinetics with random kinetic rates. Application of the model to experimental data predicts robust binding sequences in which proteins associate with the DNA at several different phases of the oscillation. Our methods circumvent the need to derive detailed kinetic graphs, and are applicable to other oscillatory biological processes involving a large number of sequential steps.
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"abstract": "In human cells, estrogenic signals induce cyclical association and\ndissociation of specific proteins with the DNA in order to activate\ntranscription of estrogen-responsive genes. These oscillations can be modeled\nby assuming a large number of sequential reactions represented by linear\nkinetics with random kinetic rates. Application of the model to experimental\ndata predicts robust binding sequences in which proteins associate with the DNA\nat several different phases of the oscillation. Our methods circumvent the need\nto derive detailed kinetic graphs, and are applicable to other oscillatory\nbiological processes involving a large number of sequential steps.",
"arxiv_id": "q-bio/0605049",
"authors": [
"Vincent Lemaire",
"Chiu Fan Lee",
"Jinzhi Lei",
"Raphael Metivier",
"Leon Glass"
],
"categories": [
"q-bio.CB",
"q-bio.MN"
],
"doi": "10.1103/PhysRevLett.96.198102",
"journal_ref": "Phys. Rev. Lett. 96, 198102 (2006)",
"title": "Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation",
"url": "https://arxiv.org/abs/q-bio/0605049"
},
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